Fronto-Limbic Connectivity as a Predictor of Improvement in Nonsuicidal Self-Injury in Adolescents Following Psychotherapy.
Identifieur interne : 000863 ( Main/Exploration ); précédent : 000862Fronto-Limbic Connectivity as a Predictor of Improvement in Nonsuicidal Self-Injury in Adolescents Following Psychotherapy.
Auteurs : Pilar Santamarina-Perez [Espagne] ; Soledad Romero [Espagne] ; Iria Mendez [Espagne] ; Sara M. Leslie [États-Unis] ; Mary M. Packer [États-Unis] ; Gisela Sugranyes [Espagne] ; Marisol Picado [Espagne] ; Elena Font [Espagne] ; Elena Moreno [Espagne] ; Esteve Martinez [Espagne] ; Astrid Morer [Espagne] ; Miguel Romero [Espagne] ; Manpreet K. Singh [États-Unis]Source :
- Journal of child and adolescent psychopharmacology [ 1557-8992 ] ; 2019.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Comportement auto-agressif (prévention et contrôle), Encéphale (imagerie diagnostique), Enfant (MeSH), Femelle (MeSH), Humains (MeSH), Imagerie par résonance magnétique (MeSH), Infections à coronavirus (traitement médicamenteux), Lobe frontal (imagerie diagnostique), Mâle (MeSH), Psychothérapie (méthodes), Système limbique (imagerie diagnostique).
- MESH :
- imagerie diagnostique : Encéphale, Lobe frontal, Système limbique.
- méthodes : Psychothérapie.
- prévention et contrôle : Comportement auto-agressif.
- traitement médicamenteux : Infections à coronavirus.
- Adolescent, Enfant, Femelle, Humains, Imagerie par résonance magnétique, Mâle.
English descriptors
- KwdEn :
- Adolescent (MeSH), Brain (diagnostic imaging), COVID-19 (drug therapy), Child (MeSH), Coronavirus Infections (drug therapy), Female (MeSH), Frontal Lobe (diagnostic imaging), Humans (MeSH), Limbic System (diagnostic imaging), Magnetic Resonance Imaging (MeSH), Male (MeSH), Psychotherapy (methods), Self-Injurious Behavior (prevention & control).
- MESH :
- diagnostic imaging : Brain, Frontal Lobe, Limbic System.
- drug therapy : COVID-19, Coronavirus Infections.
- methods : Psychotherapy.
- prevention & control : Self-Injurious Behavior.
- Adolescent, Child, Female, Humans, Magnetic Resonance Imaging, Male.
Abstract
Objectives: Key neurobiological factors contribute to vulnerability to nonsuicidal self-injury (NSSI) among adolescents and how they respond to treatment targeted to reduce such behaviors. This study aims to examine differences in intrinsic functional connectivity between adolescents with NSSI and healthy controls (HCs) and to identify baseline connectivity markers that predict improvements in NSSI after psychotherapy. Methods: Adolescents aged 12-17 (n = 24) with repetitive NSSI along with demographically similar HCs (n = 16) underwent resting-state functional MRI scanning after which patients received up to 4 months of psychological treatment. A seed-based approach was used to examine baseline between-group differences in intrinsic functional connectivity of the amygdala and the medial prefrontal cortex (mPFC). Further analyses examined the associations between intrinsic functional connectivity at baseline and improvement in NSSI after psychological treatment. Results: Compared with HCs, adolescents with NSSI showed significantly reduced connectivity between the amygdala and the anterior cingulate cortex, subcallosal cortex, and paracingulate gyrus, as well as between the amygdala and a cluster encompassing the right planum temporale and right insula. Adolescents with NSSI, compared with HCs, also showed reduced connectivity between the mPFC and two clusters: one located in the precentral and postcentral gyri and another in the left insula. After treatment, 50% of patients reported fewer NSSI episodes compared to baseline, which was considered as improvement. Stronger negative amygdala-prefrontal connectivity was associated with greater posttreatment improvement in NSSI. Conclusions: Adolescents with NSSI may have aberrant amygdala and mPFC connectivity compared with HCs. Furthermore, stronger baseline negative amygdala-prefrontal connectivity may predict greater improvement in NSSI after psychological intervention. Given that no prior study has used resting-state functional connectivity to predict response to psychological treatment in adolescents with NSSI, replication of these findings is needed.
DOI: 10.1089/cap.2018.0152
PubMed: 31225733
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>2Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>2Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>4August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 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Leslie</name><affiliation wicri:level="2"><nlm:affiliation>3Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>3Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Packer, Mary M" sort="Packer, Mary M" uniqKey="Packer M" first="Mary M" last="Packer">Mary M. Packer</name><affiliation wicri:level="2"><nlm:affiliation>3Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>3Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Sugranyes, Gisela" sort="Sugranyes, Gisela" uniqKey="Sugranyes G" first="Gisela" last="Sugranyes">Gisela Sugranyes</name><affiliation wicri:level="3"><nlm:affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>2Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>2Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>4August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>4August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Picado, Marisol" sort="Picado, Marisol" uniqKey="Picado M" first="Marisol" last="Picado">Marisol Picado</name><affiliation wicri:level="3"><nlm:affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Font, Elena" sort="Font, Elena" uniqKey="Font E" first="Elena" last="Font">Elena Font</name><affiliation wicri:level="3"><nlm:affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Moreno, Elena" sort="Moreno, Elena" uniqKey="Moreno E" first="Elena" last="Moreno">Elena Moreno</name><affiliation wicri:level="3"><nlm:affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Martinez, Esteve" sort="Martinez, Esteve" uniqKey="Martinez E" first="Esteve" last="Martinez">Esteve Martinez</name><affiliation wicri:level="3"><nlm:affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Morer, Astrid" sort="Morer, Astrid" uniqKey="Morer A" first="Astrid" last="Morer">Astrid Morer</name><affiliation wicri:level="3"><nlm:affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>2Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>2Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>4August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>4August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Romero, Miguel" sort="Romero, Miguel" uniqKey="Romero M" first="Miguel" last="Romero">Miguel Romero</name><affiliation wicri:level="3"><nlm:affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Singh, Manpreet K" sort="Singh, Manpreet K" uniqKey="Singh M" first="Manpreet K" last="Singh">Manpreet K. Singh</name><affiliation wicri:level="2"><nlm:affiliation>3Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>3Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of child and adolescent psychopharmacology</title><idno type="eISSN">1557-8992</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Brain (diagnostic imaging)</term><term>COVID-19 (drug therapy)</term><term>Child (MeSH)</term><term>Coronavirus Infections (drug therapy)</term><term>Female (MeSH)</term><term>Frontal Lobe (diagnostic imaging)</term><term>Humans (MeSH)</term><term>Limbic System (diagnostic imaging)</term><term>Magnetic Resonance Imaging (MeSH)</term><term>Male (MeSH)</term><term>Psychotherapy (methods)</term><term>Self-Injurious Behavior (prevention & control)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Comportement auto-agressif (prévention et contrôle)</term><term>Encéphale (imagerie diagnostique)</term><term>Enfant (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Imagerie par résonance magnétique (MeSH)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Lobe frontal (imagerie diagnostique)</term><term>Mâle (MeSH)</term><term>Psychothérapie (méthodes)</term><term>Système limbique (imagerie diagnostique)</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term><term>Frontal Lobe</term><term>Limbic System</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>COVID-19</term><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Encéphale</term><term>Lobe frontal</term><term>Système limbique</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Psychotherapy</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Psychothérapie</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Self-Injurious Behavior</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Comportement auto-agressif</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><b><i>Objectives:</i></b> Key neurobiological factors contribute to vulnerability to nonsuicidal self-injury (NSSI) among adolescents and how they respond to treatment targeted to reduce such behaviors. This study aims to examine differences in intrinsic functional connectivity between adolescents with NSSI and healthy controls (HCs) and to identify baseline connectivity markers that predict improvements in NSSI after psychotherapy. <b><i>Methods:</i></b> Adolescents aged 12-17 (<i>n</i> = 24) with repetitive NSSI along with demographically similar HCs (<i>n</i> = 16) underwent resting-state functional MRI scanning after which patients received up to 4 months of psychological treatment. A seed-based approach was used to examine baseline between-group differences in intrinsic functional connectivity of the amygdala and the medial prefrontal cortex (mPFC). Further analyses examined the associations between intrinsic functional connectivity at baseline and improvement in NSSI after psychological treatment. <b><i>Results:</i></b> Compared with HCs, adolescents with NSSI showed significantly reduced connectivity between the amygdala and the anterior cingulate cortex, subcallosal cortex, and paracingulate gyrus, as well as between the amygdala and a cluster encompassing the right planum temporale and right insula. Adolescents with NSSI, compared with HCs, also showed reduced connectivity between the mPFC and two clusters: one located in the precentral and postcentral gyri and another in the left insula. After treatment, 50% of patients reported fewer NSSI episodes compared to baseline, which was considered as improvement. Stronger negative amygdala-prefrontal connectivity was associated with greater posttreatment improvement in NSSI. <b><i>Conclusions:</i></b> Adolescents with NSSI may have aberrant amygdala and mPFC connectivity compared with HCs. Furthermore, stronger baseline negative amygdala-prefrontal connectivity may predict greater improvement in NSSI after psychological intervention. Given that no prior study has used resting-state functional connectivity to predict response to psychological treatment in adolescents with NSSI, replication of these findings is needed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31225733</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>16</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-8992</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>6</Issue><PubDate><Year>2019</Year><Month>08</Month></PubDate></JournalIssue><Title>Journal of child and adolescent psychopharmacology</Title><ISOAbbreviation>J Child Adolesc Psychopharmacol</ISOAbbreviation></Journal><ArticleTitle>Fronto-Limbic Connectivity as a Predictor of Improvement in Nonsuicidal Self-Injury in Adolescents Following Psychotherapy.</ArticleTitle><Pagination><MedlinePgn>456-465</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/cap.2018.0152</ELocationID><Abstract><AbstractText><b><i>Objectives:</i></b> Key neurobiological factors contribute to vulnerability to nonsuicidal self-injury (NSSI) among adolescents and how they respond to treatment targeted to reduce such behaviors. This study aims to examine differences in intrinsic functional connectivity between adolescents with NSSI and healthy controls (HCs) and to identify baseline connectivity markers that predict improvements in NSSI after psychotherapy. <b><i>Methods:</i></b> Adolescents aged 12-17 (<i>n</i> = 24) with repetitive NSSI along with demographically similar HCs (<i>n</i> = 16) underwent resting-state functional MRI scanning after which patients received up to 4 months of psychological treatment. A seed-based approach was used to examine baseline between-group differences in intrinsic functional connectivity of the amygdala and the medial prefrontal cortex (mPFC). Further analyses examined the associations between intrinsic functional connectivity at baseline and improvement in NSSI after psychological treatment. <b><i>Results:</i></b> Compared with HCs, adolescents with NSSI showed significantly reduced connectivity between the amygdala and the anterior cingulate cortex, subcallosal cortex, and paracingulate gyrus, as well as between the amygdala and a cluster encompassing the right planum temporale and right insula. Adolescents with NSSI, compared with HCs, also showed reduced connectivity between the mPFC and two clusters: one located in the precentral and postcentral gyri and another in the left insula. After treatment, 50% of patients reported fewer NSSI episodes compared to baseline, which was considered as improvement. Stronger negative amygdala-prefrontal connectivity was associated with greater posttreatment improvement in NSSI. <b><i>Conclusions:</i></b> Adolescents with NSSI may have aberrant amygdala and mPFC connectivity compared with HCs. Furthermore, stronger baseline negative amygdala-prefrontal connectivity may predict greater improvement in NSSI after psychological intervention. Given that no prior study has used resting-state functional connectivity to predict response to psychological treatment in adolescents with NSSI, replication of these findings is needed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Santamarina-Perez</LastName><ForeName>Pilar</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romero</LastName><ForeName>Soledad</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>2Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mendez</LastName><ForeName>Iria</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leslie</LastName><ForeName>Sara M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>3Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Packer</LastName><ForeName>Mary M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>3Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sugranyes</LastName><ForeName>Gisela</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>2Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>4August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Picado</LastName><ForeName>Marisol</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Font</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moreno</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martinez</LastName><ForeName>Esteve</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morer</LastName><ForeName>Astrid</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>2Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>4August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romero</LastName><ForeName>Miguel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>1Department of Child and Adolescent Psychiatry and Psychology, 2017SGR88, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singh</LastName><ForeName>Manpreet K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>3Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>06</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Child Adolesc Psychopharmacol</MedlineTA><NlmUniqueID>9105358</NlmUniqueID><ISSNLinking>1044-5463</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005625" MajorTopicYN="N">Frontal Lobe</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008032" MajorTopicYN="N">Limbic System</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011613" MajorTopicYN="N">Psychotherapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016728" MajorTopicYN="N">Self-Injurious Behavior</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">NSSI</Keyword><Keyword MajorTopicYN="Y">amygdala</Keyword><Keyword MajorTopicYN="Y">brain connectivity</Keyword><Keyword MajorTopicYN="Y">medial prefrontal cortex</Keyword><Keyword MajorTopicYN="Y">psychological intervention</Keyword><Keyword MajorTopicYN="Y">resting state</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>6</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>6</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31225733</ArticleId><ArticleId IdType="doi">10.1089/cap.2018.0152</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li><li>États-Unis</li></country><region><li>Californie</li><li>Catalogne</li><li>Communauté de Madrid</li></region><settlement><li>Barcelone</li><li>Madrid</li></settlement></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Santamarina Perez, Pilar" sort="Santamarina Perez, Pilar" uniqKey="Santamarina Perez P" first="Pilar" last="Santamarina-Perez">Pilar Santamarina-Perez</name></region><name sortKey="Font, Elena" sort="Font, Elena" uniqKey="Font E" first="Elena" last="Font">Elena Font</name><name sortKey="Martinez, Esteve" sort="Martinez, Esteve" uniqKey="Martinez E" first="Esteve" last="Martinez">Esteve Martinez</name><name sortKey="Mendez, Iria" sort="Mendez, Iria" uniqKey="Mendez I" first="Iria" last="Mendez">Iria Mendez</name><name sortKey="Moreno, Elena" sort="Moreno, Elena" uniqKey="Moreno E" first="Elena" last="Moreno">Elena Moreno</name><name sortKey="Morer, Astrid" sort="Morer, Astrid" uniqKey="Morer A" first="Astrid" last="Morer">Astrid Morer</name><name sortKey="Morer, Astrid" sort="Morer, Astrid" uniqKey="Morer A" first="Astrid" last="Morer">Astrid Morer</name><name sortKey="Morer, Astrid" sort="Morer, Astrid" uniqKey="Morer A" first="Astrid" last="Morer">Astrid Morer</name><name sortKey="Picado, Marisol" sort="Picado, Marisol" uniqKey="Picado M" first="Marisol" last="Picado">Marisol Picado</name><name sortKey="Romero, Miguel" sort="Romero, Miguel" uniqKey="Romero M" first="Miguel" last="Romero">Miguel Romero</name><name sortKey="Romero, Soledad" sort="Romero, Soledad" uniqKey="Romero S" first="Soledad" last="Romero">Soledad Romero</name><name sortKey="Romero, Soledad" sort="Romero, Soledad" uniqKey="Romero S" first="Soledad" last="Romero">Soledad Romero</name><name sortKey="Sugranyes, Gisela" sort="Sugranyes, Gisela" uniqKey="Sugranyes G" first="Gisela" last="Sugranyes">Gisela Sugranyes</name><name sortKey="Sugranyes, Gisela" sort="Sugranyes, Gisela" uniqKey="Sugranyes G" first="Gisela" last="Sugranyes">Gisela Sugranyes</name><name sortKey="Sugranyes, Gisela" sort="Sugranyes, Gisela" uniqKey="Sugranyes G" first="Gisela" last="Sugranyes">Gisela Sugranyes</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Leslie, Sara M" sort="Leslie, Sara M" uniqKey="Leslie S" first="Sara M" last="Leslie">Sara M. Leslie</name></region><name sortKey="Packer, Mary M" sort="Packer, Mary M" uniqKey="Packer M" first="Mary M" last="Packer">Mary M. Packer</name><name sortKey="Singh, Manpreet K" sort="Singh, Manpreet K" uniqKey="Singh M" first="Manpreet K" last="Singh">Manpreet K. Singh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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